MRA-2

Name: Nasal – MRA-2 40mg
SKU: MRA2n40
Price: 366.00 USD
Availability: InStock

40mg

Nasal/Oral Spray

$366.00

Name:

Metabolic Receptor Agonist -2
Sequence*:

H-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Ahx-Ahx-Lys-NH₂ (C20 fatty diacid moiety attached via linker)
Molecular Formula*:

C₂₂₅H₃₆₃N₄₈O₆₈
Molecular Weight*:

≈ 4813.55 g/mol
CAS Registry Number:

2023788-19-2

* Typical formulation

MRA-2 – COMPREHENSIVE RESEARCH PEPTIDE FOR INCRETIN AND DUAL RECEPTOR SIGNALING STUDIES

Scientific Overview of MRA-2

MRA-2 is a synthetic dual receptor agonist peptide that acts on both the Glucagon-Like Peptide-1 (GLP-1) and Glucose-Dependent Insulinotropic Polypeptide (GIP) receptors. It is structurally based on the native GIP sequence, modified to include fatty acid side-chain conjugation for increased plasma stability and receptor binding persistence.

In preclinical and mechanistic studies, Dual Agonist (GLP-1 / GIP) has been investigated for its role in metabolic and endocrine research models, focusing on:

• Dual Receptor Activation – exploration of concurrent GLP-1R and GIPR binding and downstream cAMP pathway signaling (Frias et al., 2018)
• Metabolic Pathway Integration – study of peptide-mediated modulation of glucose metabolism and lipid utilization (Coskun et al., 2018)
• Structural Optimization and Acylation Modifications – evaluation of long-chain fatty acid conjugation and receptor selectivity enhancements (Willard et al., 2020)

This peptide serves as a key research tool for examining incretin biology, dual receptor dynamics, and peptide engineering aimed at understanding complex metabolic signaling processes.

*These products are not intended to diagnose, treat, cure, or prevent any disease. Research compounds are sold for laboratory and educational purposes only, not for human or animal use.